This symposium will focus on practical and evidence-based aspects of managing the difficult GI disorders in gastroenterology and hepatology practice. This 3-day symposium will provide guidance to attendees on diagnostics and management of challenging cases in clinical practice and latest advances in the field, including esophageal diseases, liver disease, inflammatory bowel disease, small bowel and pancreatic diseases, and endoscopy. Each session will include didactic presentations followed by a panel discussion about the optimal approach to the diagnosis and management of the presented topics.